Group of Nuclear Genomics

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Faculty staff

Prof. Dr. Toshio Yamamoto
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Associate Prof. Dr. Kiyotaka Nagaki
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Lectures: Analytical Molecular Cytogenetics
Keywords: Centromere; Artificial chromosome; Nucleus; Chromatin

Summary of main research topics

Exploring and utilization of useful traits from diverse rice genetic resources
Rice is cultivated all around the world and shows numerous morphological and physiological differences in the form of phenotypic variations. Some of these variations have been used as genetic resources to improve rice plants so that they better satisfy human needs. Phenotypic variations are considered to be genetically controlled by the collective function of a large number of genes on rice genomes However, the genetic bases and biological functions of most of them are still unknown, which has prevented us from wider practical application of rice germplasms. We exploit useful phenotypic variations from a wide range of rice germplasms and clarify the genes involved with biological functions by aid of recent advances in genome information and technology. Also, we try to develop new breeding materials and propose more effective breeding methodologies. Design and synthesis of ‘chromosomes’ carrying new genome information
Nuclei that have very complex structures and various functions are the most important organelles in eukaryotic cells. Nuclear DNA are divided and packed into chromosomes, enabling the accurate transmission of genetic information to daughter cells. Our research group is studying the molecular structures and functions of nuclei and chromosomes, mainly in plants. Our most recent goal is the development of plant artificial chromosomes to elucidate chromosome functional elements: centromeres, telomeres, and replication origins. We are also interested in the relation between chromatin modifications and gene expression.

Latest publications (for complete and most current publications visit group pages)

(1) Nagaki, K., Yamaji, N. and Murata, M. ePro-ClearSee: a simple immunohistochemical method that does not require sectioning of plant samples. Scientific Reports 7: srep42203. (2017. 2.)
(2) Fukuda A, Kondo K, Ikka T, Takai T, Tanabata T, Yamamoto T (2018) A novel QTL associated with rice canopy temperature difference affects stomatal conductance and leaf photosynthesis. Breeding Science
(3) Mulsanti IW, Yamamoto T, Ueda T, Samadi AF, Kamahora E, Rumanti IA, Thanh VC, Adachi S, Suzuki S, Kanekatsu M, Hirasawa T, Ookawa T (2018) Finding the superior allele of japonica-type for increasing stem lodging resistance in indica rice varieties using chromosome segment substitution lines. Rice 11:25
(4) Ogawa D, Yamamoto E, Ootani T, Kanno N, Tsunematsu H, Nonoue Y, Yano M, Yamamoto T, Yonemaru J (2018) Haplotype-based allele mining with JAPAN MAGIC population in rice. Scientific Reports 8:4379