{"id":101,"date":"2018-08-04T18:24:59","date_gmt":"2018-08-04T09:24:59","guid":{"rendered":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/?p=101"},"modified":"2021-10-14T09:07:32","modified_gmt":"2021-10-14T00:07:32","slug":"%e3%81%9d%e3%81%ae%e4%bb%96%e3%81%ae%e5%a4%89%e7%95%b0%e6%a0%aa","status":"publish","type":"post","link":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/research3.html","title":{"rendered":"\u305d\u306e\u4ed6\u306e\u5909\u7570\u682a"},"content":{"rendered":"<p><strong>\uff0a \u7d30\u80de\u58c1\u5f62\u6210\u95a2\u9023\u5909\u7570 <em>shv3<\/em><\/strong><br \/>\n\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306e\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u633f\u5165\u5909\u7570\u30e9\u30a4\u30f3\u3092\u5229\u7528\u3057\u3066\u3001\u7d30\u80de\u58c1\u5f62\u6210\u5909\u7570\u682ashv3\u3092\u5206\u96e2\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u5909\u7570\u682a\u306f\u5143\u3005\u6839\u6bdb\u304c\u3067\u304d\u306a\u3044\u8868\u73fe\u578b\u3067\u9078\u629c\u3055\u308c\u305f\u306e\u3067\u3059\u304c\u3001\u8a73\u7d30\u306a\u89e3\u6790\u304b\u3089\u3053\u306e\u5909\u7570\u682a\u3067\u306f\u7d30\u80de\u58c1\u306e\u5f62\u6210\u306b\u7570\u5e38\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u985e\u4f3c\u907a\u4f1d\u5b50<em>SVL1<\/em>\u306e\u7834\u58ca\u5909\u7570\u306e\u591a\u91cd\u5909\u7570\u682a\u3067\u306f\u3001\u6839\u6bdb\u4ee5\u5916\u306b\u3082\u69d8\u3005\u306a\u8868\u73fe\u578b\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u539f\u56e0\u907a\u4f1d\u5b50\u306f\u690d\u7269\u7279\u6709\u306e\u907a\u4f1d\u5b50\u3067\u3001\u4eca\u5f8c\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u308c\u3070\u3001\u7d30\u80de\u58c1\u5f62\u6210\u306b\u3064\u3044\u3066\u65b0\u305f\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p align=\"center\"><span style=\"color: #990000;\">\u6839\u6bdb\u306e\u69d8\u5b50<\/span> \u3000\u3000\u3000 &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;\u3000\u3000\u3000\u3000\u3000\u3000\u3000<span style=\"color: #990000;\"><em>shv3svl1<\/em>\u4e8c\u91cd\u5909\u7570\u682a\u306e\u80da\u8ef8\u306e\u69d8\u5b50<\/span><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.rib.okayama-u.ac.jp\/ers\/image\/SHV3.jpg\" alt=\"\" width=\"226\" height=\"193\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.rib.okayama-u.ac.jp\/ers\/image\/shv3-2.jpg\" alt=\"\" width=\"314\" height=\"118\"><\/p>\n<p><strong>\uff0a\u30af\u30c1\u30af\u30e9\u5c64\u5f62\u6210\u95a2\u9023\u5909\u7570 <em>cof1<\/em><\/strong><br \/>\n\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u633f\u5165\u5909\u7570\u30e9\u30a4\u30f3\u304b\u3089\u8449\u304c\u7652\u7740\u3059\u308b\u5909\u308f\u3063\u305f\u5909\u7570\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002\u8a73\u7d30\u306a\u89e3\u6790\u304b\u3089\u3053\u306e\u5909\u7570\u682a\u306f\u3001\u690d\u7269\u7d30\u80de\u306e\u8868\u76ae\u3092\u4e7e\u71e5\u3084\u75c5\u5bb3\u866b\u304b\u3089\u306e\u653b\u6483\u304b\u3089\u5b88 \u308b\u30af\u30c1\u30af\u30e9\u5c64\u306e\u5f62\u6210\u306b\u95a2\u308f\u308b\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002COF1\u306f\u819c\u3092\u4ecb\u3057\u305f\u7269\u8cea\u306e\u8f38\u9001\u306b\u95a2\u308f\u3063\u3066\u3044\u308bABC\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3068\u547c\u3070\u308c\u308b\u4e00\u9023\u306e\u30bf\u30f3\u30d1 \u30af\u8cea\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5c5e\u3057\u3001\u89e3\u6790\u306e\u7d50\u679c\u304b\u3089\u8102\u8cea\u306e\u8f38\u9001\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p align=\"center\"><span style=\"color: #990000;\">\u690d\u7269\u4f53\u306e\u69d8\u5b50<\/span> \u3000\u3000\u3000 &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;\u3000\u3000\u3000\u3000\u3000\u3000\u3000<span style=\"color: #990000;\">\u8d70\u67fb\u96fb\u5b50\u9855\u5fae\u93e1\u306b\u3088\u308b\u8868\u76ae\u306e\u89b3\u5bdf\u50cf<\/span><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.rib.okayama-u.ac.jp\/ers\/image\/COF1.jpg\" alt=\"\" width=\"232\" height=\"104\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.rib.okayama-u.ac.jp\/ers\/image\/cof2.jpg\" alt=\"\" width=\"315\" height=\"106\"><\/p>\n<p style=\"padding-left: 30px;\">\u5de6\u56f3: \u91ce\u751f\u682a\uff08\u5de6\uff09\u3068<em>cof1<\/em> \u5909\u7570\u682a\uff08\u53f3\uff09\u306e\u690d\u7269\u4f53\u306e\u69d8\u5b50 (bar=10 mm)\u3002<em>cof1<\/em>\u5909\u7570\u682a\u3067\u306f\u672c\u8449\u304c\u878d\u5408\u3057\u3066\u3044\u308b\u3002\u53f3\u56f3: \u8d70\u67fb\u96fb\u5b50\u9855\u5fae\u93e1\u306b\u3088\u308b\u8868\u76ae\u306e\u72b6\u614b (bar=5 \u03bcm)\u3002\u91ce\u751f\u682a\uff08\u5de6\uff09\u3067\u306f\u7d50\u6676\u5316\u3057\u305f\u30ef\u30c3\u30af\u30b9\u306e\u69cb\u9020\u4f53\u304c\u898b\u3089\u308c\u308b\u304c\u3001<em>cof1<\/em>\u5909\u7570\u682a (\u53f3) \u3067\u306f\u307b\u3068\u3093\u3069\u898b\u3089\u308c\u306a\u3044\u3002<\/p>\n<p><strong>\uff0a\u30a8\u30bf\u30ce\u30fc\u30eb\u9ad8\u611f\u53d7\u6027\u5909\u7570 <\/strong><em><strong>gek1<\/strong><\/em><br \/>\n\u5909\u7570\u682a\u3092\u53ce\u96c6\u3057\u3066\u3044\u308b\u904e\u7a0b\u3067\u30a8\u30bf\u30ce\u30fc\u30eb\u306b\u9ad8\u611f\u53d7\u6027\u3092\u793a\u3059\u5909\u7570\u682a\u3092\u53d6\u5f97\u3057\u3001<em>geko1&nbsp;<\/em>(\u4e0b\u62381) \u3068\u540d\u4ed8\u3051\u307e\u3057\u305f\u3002<em>geko1&nbsp;<\/em>(<em>gek1<\/em>) \u306f\u3001\u91ce\u751f\u682a\u306e100\u500d\u7a0b\u5ea6\u5f37\u304f\u30a8\u30bf\u30ce\u30fc\u30eb\u306b\u611f\u53d7\u6027\u3092\u793a\u3057\u307e\u3059\u3002\u4ed6\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u3078\u306e\u5fdc\u7b54\u3084\u3001\u4ed6\u306e\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u5fdc\u7b54\u306b\u306f\u5f71\u97ff\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u901a\u5e38\u306e\u751f\u80b2\u306b\u3082\u4f55\u3089 \u5f71\u97ff\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u89e3\u6790\u306e\u7d50\u679c\u3001\u30a8\u30bf\u30ce\u30fc\u30eb\u304b\u3089\u4f5c\u3089\u308c\u305f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306b\u611f\u53d7\u6027\u3092\u793a\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<em>geko1<\/em>\u5909\u7570\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3092\u540c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001\u690d\u7269\u3068\u53e4\u7d30\u83cc\u306b\u306e\u307f\u898b\u3044\u3060\u3055\u308c \u308b\u4eca\u307e\u3067\u306b\u5831\u544a\u306e\u306a\u3044\u907a\u4f1d\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001GEK1\u306fD-aminoacyl-tRNA-acylase\u306e\u6d3b\u6027\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u6d3b\u6027\u3068\u30a8\u30bf\u30ce\u30fc\u30eb\u611f\u53d7\u6027\u3068\u306e\u95a2\u4fc2\u306f\u307e\u3060\u4e0d\u660e\u3067\u3059\u3002\u4eca\u5f8c\u306e\u89e3\u6790\u306b\u3088\u308a\u3001\u3053\u308c\u307e\u3067\u306b\u77e5\u3089\u308c\u3066\u3044\u306a\u3044\u690d\u7269\u304c\u6301\u3064\u79d8\u5bc6\u304c\u308f\u304b\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p align=\"center\">\u3000\u3000\u3000<span style=\"color: #990000;\">\u30a8\u30bf\u30ce\u30fc\u30eb\u5b58\u5728\u4e0b\u3067\u306e\u767a\u82bd\u8a66\u9a13<\/span> &nbsp; &nbsp; &nbsp;&nbsp;\u3000\u3000\u3000<span style=\"color: #990000;\">GEK1\u9ad8\u767a\u73fe\u690d\u7269\u4f53 \u306e\u30a8\u30bf\u30ce\u30fc\u30eb\u8010\u6027<\/span><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.rib.okayama-u.ac.jp\/ers\/image\/GEK1.jpg\" alt=\"\" width=\"255\" height=\"143\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.rib.okayama-u.ac.jp\/ers\/image\/GEK1OX.jpg\" alt=\"\" width=\"201\" height=\"169\"><\/p>\n<p style=\"padding-left: 30px;\">\u5de6\u56f3:0.01%\u3068\u3044\u3046\u4f4e\u6fc3\u5ea6\u3067\u3082\u3001<em>geko1<\/em>\u5909\u7570\u682a(<em>gek1-1, 1-2, 1-3<\/em>)\u3067\u306f\u3001\u767a\u82bd\u304c\u8457\u3057\u304f\u963b\u5bb3\u3055\u308c\u308b\u3002 (Hirayama et al. PCP, 45, 703- )\u3002\u53f3\u56f3:\uff13\uff05 \u30a8\u30bf\u30ce\u30fc\u30eb\u5b58\u5728\u4e0b\u3067\u751f\u80b2\u3055\u305b\u305f\u91ce\u751f\u682a\uff08\u5de6\uff09\u3068GEK1\u9ad8\u767a\u73fe\u5f62\u8cea\u8ee2\u63db\u4f53\u690d \u7269\uff08\u53f3\uff09(Fujishige et al. PCP, 45, 659-)\u3002<\/p>\n<p>&gt;&gt;&gt; <a href=\"http:\/\/www.rib.okayama-u.ac.jp\/ers\/research2.html\"> \u30a2\u30d6\u30b7\u30b8\u30f3\u9178\u5fdc\u7b54\u6a5f\u69cb\u306e\u89e3\u6790<\/a><br \/>\n&gt;&gt;&gt;<a href=\"http:\/\/www.rib.okayama-u.ac.jp\/ers\/archives\/1034\"> \u30c7\u30fc\u30bf\u99c6\u52d5\u578b\u4f5c\u7269\u30c7\u30b6\u30a4\u30f3\u6280\u8853\u306e\u958b\u767a<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff0a \u7d30\u80de\u58c1\u5f62\u6210\u95a2\u9023\u5909\u7570 shv3 \u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306e\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u633f\u5165\u5909\u7570\u30e9\u30a4\u30f3\u3092\u5229\u7528\u3057\u3066\u3001\u7d30\u80de\u58c1\u5f62\u6210\u5909\u7570\u682ashv3\u3092\u5206\u96e2\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u5909\u7570\u682a\u306f\u5143\u3005\u6839\u6bdb\u304c\u3067\u304d\u306a\u3044\u8868\u73fe\u578b\u3067\u9078\u629c\u3055\u308c\u305f\u306e\u3067\u3059\u304c\u3001\u8a73\u7d30\u306a\u89e3\u6790\u304b\u3089\u3053\u306e\u5909\u7570\u682a\u3067\u306f\u7d30\u80de &hellip; <a href=\"http:\/\/www.rib.okayama-u.ac.jp\/ers\/research3.html\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-101","post","type-post","status-publish","format-standard","hentry","category-reserch"],"_links":{"self":[{"href":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/wp-json\/wp\/v2\/posts\/101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/wp-json\/wp\/v2\/comments?post=101"}],"version-history":[{"count":12,"href":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/wp-json\/wp\/v2\/posts\/101\/revisions"}],"predecessor-version":[{"id":1185,"href":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/wp-json\/wp\/v2\/posts\/101\/revisions\/1185"}],"wp:attachment":[{"href":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/wp-json\/wp\/v2\/media?parent=101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/wp-json\/wp\/v2\/categories?post=101"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.rib.okayama-u.ac.jp\/ers\/wp-json\/wp\/v2\/tags?post=101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}