{"id":22,"date":"2020-01-09T16:53:40","date_gmt":"2020-01-09T07:53:40","guid":{"rendered":"https:\/\/www.rib.okayama-u.ac.jp\/plant_design\/?page_id=22"},"modified":"2023-04-07T13:03:28","modified_gmt":"2023-04-07T04:03:28","slug":"research","status":"publish","type":"page","link":"https:\/\/www.rib.okayama-u.ac.jp\/plant_design\/?page_id=22","title":{"rendered":"RESEARCH"},"content":{"rendered":"<h2>\u30a4\u30cd\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u540c\u5b9a\u3068\u6a5f\u80fd\u89e3\u6790<\/h2>\n<p>\u690d\u7269\u306b\u304a\u3044\u3066\u306f\u3001\u52d5\u7269\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306b\u985e\u4f3c\u3057\u305f\u5185\u56e0\u6027\u30d8\u309a\u30d5\u309a\u30c1\u30c8\u3099\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u690d\u7269\u306b\u304a\u3051\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u540c\u5b9a\u306f\u91cd\u8981\u304b\u3064\u6311\u6226\u7684\u306a\u76ee\u6a19\u3066\u3099\u3042\u3063\u305f\u3002\u79c1\u9054\u306f\u3001\u690d\u7269\u514d\u75ab\u306b\u95a2\u4e0e\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d5\u309a\u30c8\u30fc\u30e0\u89e3\u6790\u3068\u30d5\u309a\u30ed\u30c6\u30aa\u30fc \u30e0\u89e3\u6790\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u300c\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u89e3\u6790\u300d\u306b\u57fa\u3064\u3099\u3044\u305f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30af\u3099\u3092\u7528\u3044\u3066\u3001\u30a4\u30cd\u3044\u3082\u3061\u75c5\u83cc\u3068\u305d\u306e\u30a8\u30ea\u30b7\u30bf\u30fc\u3066\u3099\u3042\u308b\u30ad\u30c1\u30f3\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b236\u500b\u306e\u5185\u56e0\u6027\u5206\u6ccc\u30d8\u309a\u30d5\u309a\u30c1\u30c8\u3099 (SSP) \u3092\u540c\u5b9a\u3057\u305f(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31301098\/\">Wang et al., Plant Biotech J 2020<\/a>)\u3002\u3053\u308c\u3089\u306eSSP\u306b\u306f\u3001\u65e2\u77e5\u306e2\u3064\u306e\u30d8\u309a\u30d5\u309a\u30c1\u30c8\u3099 \u30d5\u30a1\u30df\u30ea\u30fc\u306eRALF7\u3068PSK4\u304b\u3099\u542b\u307e\u308c\u3066\u3044\u305f\u3002\u3055\u3089\u306b\u3001\u30a4\u30cd\u306e\u514d\u75ab\u306b\u95a2\u4e0e\u3059\u308b\u65b0\u898f\u30b5\u30a4\u30c8\u30ab \u30a4\u30f3\u30d5\u30a1\u30df\u30ea\u30fc\u3068\u3057\u3066IRP\u3092\u540c\u5b9a\u3057\u305f\u3002\u672c\u7814\u7a76\u306f\u3001\u30a4\u30cd\u304b\u3099\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u4ecb\u3057\u3066\u514d\u75ab\u3092\u5236\u5fa1 \u3059\u308b\u4ed5\u7d44\u307f\u306e\u7406\u89e3\u306b\u5927\u304d\u304f\u8ca2\u732e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002\u3055\u3089\u306b\u3001\u79c1\u9054\u306f\u3001IRP\u304b\u3099\u30a4\u30cd\u306e\u6700\u91cd \u8981\u75c5\u5bb3\u3066\u3099\u3042\u308b\u3044\u3082\u3061\u75c5\u83cc\u306b\u5bfe\u3059\u308b\u62b5\u6297\u6027\u306b\u304a\u3044\u3066\u6b63\u306e\u5236\u5fa1\u56e0\u5b50\u3066\u3099\u3042\u308b\u3053\u3068\u3001MAPK\u6d3b\u6027\u5316\u3084 WRKY\u8ee2\u5199\u56e0\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3057\u3066\u30a4\u30cd\u8010\u75c5\u6027\u3092\u5411\u4e0a\u3055\u305b\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f(<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.01.31.429004v1\">Wang et al., bioRxiv 2021<\/a>)\u3002<br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-294 aligncenter\" src=\"https:\/\/www.rib.okayama-u.ac.jp\/plant_design\/wp-content\/uploads\/2021\/04\/f3.jpg\" alt=\"\" width=\"420\" height=\"310\" \/><\/p>\n<h2>\u514d\u75ab\u53d7\u5bb9\u4f53NLR\u30bf\u30f3\u30d1\u30af\u8ceaPit\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u89e3\u660e<\/h2>\n<p>NLR \u30bf\u30f3\u30cf\u309a\u30af\u8cea\u306f\u3001\u690d\u7269\u514d\u75ab\u306e\u91cd\u8981\u306a\u7d30\u80de\u5185\u53d7\u5bb9\u4f53\u3066\u3099\u3042\u308b\u3002\u79c1\u9054\u306f\u3001OsRac1 \u306e\u6d3b\u6027\u5316\u30e1\u30ab\u30cb\u30b9\u3099\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u7d50\u5408\u30bf\u30f3\u30cf\u309a\u30af\u8cea\u306e\u63a2\u7d22\u3092\u884c\u3044\u3001\u30a4\u30cd\u306e\u6700\u91cd\u8981\u75c5\u5bb3\u3066\u3099\u3042\u308b \u3044\u3082\u3061\u75c5\u83cc\u306e\u514d\u75ab\u53d7\u5bb9\u4f53\u3066\u3099\u3042\u308b NLR \u578b\u30bf\u30f3\u30cf\u309a\u30af\u8cea Pit \u3092\u540c\u5b9a\u3057\u3001Pit \u306b\u3088\u308b OsRac1 \u306e\u5236\u5fa1 \u304b\u3099\u3044\u3082\u3061\u75c5\u83cc\u3078\u306e\u9632\u5fa1\u5fdc\u7b54\u306b\u91cd\u8981\u3066\u3099\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20478538\/\">Kawano et al., Cell Host Microbe 2010<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25352853\/\">Kawano et al., Front Plant Sci. 2014<\/a>)\u3002\u3055\u3089\u306b\u3001Pit\u304b\u3099OsSPK1\u3068\u547c\u306f\u3099\u308c\u308bG\u30bf\u30f3\u30cf\u309a\u30af\u8cea\u306e\u6d3b\u6027\u5316\u30bf\u30f3\u30cf\u309a\u30af\u8cea\u3092\u4ecb\u3057\u3066\u3001OsRac1 \u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30446614\/\">Wang et al., PNAS 2018<\/a>)\u3002\u307e\u305f\u3001\u8102\u8cea\u4fee\u98fe (\u30cf\u309a\u30eb\u30df\u30c8\u30a4\u30eb\u5316) \u3092\u4ecb\u3057\u3066 Pit1 \u304b\u3099\u7d30\u80de\u819c\u306b\u30a2\u30f3\u30ab\u30fc\u3059\u308b\u3053\u3068\u304b\u3099\u3001Pit \u306b\u3088\u308b\u7d30\u80de\u819c\u4e0a\u3066\u3099\u306e OsRac1 \u6d3b\u6027\u5316\u306b\u5fc5\u9808\u3066\u3099\u3042\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u308b(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24841201\/\">Kawano et al., JBC 2014<\/a>)\u3002<br \/>\n\u3053\u308c\u3089\u306e\u767a\u898b\u306b\u3088\u308a\u3001\u690d\u7269\u306e\u4e2d\u3066\u3099\u6700\u3082\u5f37\u3044\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3059 NLR \u514d\u75ab\u53d7\u5bb9\u4f53\u306e\u4e3b\u8981\u306a\u30b7\u30af\u3099\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-19 aligncenter\" src=\"https:\/\/www.rib.okayama-u.ac.jp\/plant_design\/wp-content\/uploads\/2020\/01\/f1.png\" alt=\"\" width=\"350\" height=\"221\" \/><\/p>\n<h2>\u30cf\u309a\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53\u306b\u3088\u308bOsRac1\u3092\u4ecb\u3057\u305f\u8010\u75c5\u6027\u8a98\u5c0e\u6a5f\u69cb<\/h2>\n<p>\u79c1\u9054\u306f\u3001\u4f4e\u5206\u5b50\u91cfG\u30bf\u30f3\u30cf\u309a\u30af\u8ceaOsRac1\u304b\u3099\u819c\u8cab\u901a\u578b\u306e\u514d\u75ab\u53d7\u5bb9\u4f53\u3066\u3099\u3042\u308b\u30cf\u309a\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53\u306e\u30b7\u30af\u3099\u30ca\u30eb\u9375\u56e0\u5b50\u3066\u3099\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u308b(<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.07.01.183301v1.full\">Akamatsu et al., bioRxiv 2020<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27465023\/\">Nagano et al., Plant Cell 2016<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27499679\/\">Akamatsu et al., Curr Genomic 2016<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23927868\/\">Kawano and Shimamoto, Curr Opin Plant Biol 2013<\/a>)\u3002OsRac1\u306f\u3001\u30a4\u30cd\u514d\u75ab\u3092\u5236\u5fa1\u3059\u308b\u30de\u30b9\u30bf\u30fc\u30ec\u30ad\u3099\u30e5\u30ec\u30fc\u30bf\u30fc\u3066\u3099\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u690d\u7269\u7d30\u80de\u5185\u3066\u3099OsRac1\u6d3b\u6027\u5316\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30af\u3099\u3059\u308b\u3053\u3068\u306f\u3001\u690d\u7269\u514d\u75ab\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3066\u3099\u91cd\u8981\u3066\u3099\u3042\u308b\u3068\u8003\u3048\u305f\u3002\u86cd\u5149\u30bf\u30f3\u30cf\u309a\u30af\u8cea\u306e\u86cd\u5149\u5171\u9cf4\u30a8\u30cd\u30eb\u30ad\u3099\u30fc\u79fb\u52d5\u3092\u7528\u3044\u305f\u30cf\u3099\u30a4\u30aa\u30a4\u30e1\u30fc\u30b7\u3099\u30f3\u30af\u3099\u30bb\u30f3\u30b5\u30fc\u3092\u6a39\u7acb\u3057\u3001\u3044\u3082\u3061\u75c5\u83cc\u306e\u7d30\u80de\u58c1\u6210\u5206\u3092\u611f\u77e5\u3057\u3066\u304b\u30893\u5206\u4ee5\u5185\u306bOsRac1\u304b\u3099\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30002723\/\">Wong et al., Plant Methods 2018<\/a>)\u3002\u3053\u308c\u306f\u4f4e\u5206\u5b50\u91cfG\u30bf\u30f3\u30cf\u309a\u30af\u8cea\u306e\u6d3b\u6027\u5316\u3092\u690d\u7269\u306e\u751f\u7d30\u80de\u3066\u3099\u89b3\u5bdf\u3057\u305f\u521d\u3081\u3066\u306e\u4e8b\u4f8b\u3066\u3099\u3042\u308b\u3002\u3055\u3089\u306b\u3001\u30ad\u30c1\u30f3\u53d7\u5bb9\u4f53OsCERK1\u304b\u3089\u306e\u6307\u4ee4\u304b\u3099\u3001OsRac1\u306e \u6d3b\u6027\u5316\u30bf\u30f3\u30cf\u309a\u30af\u8ceaOsRacGEF1 \u3092\u4ecb\u3057\u3066OsRac1\u306b\u4f1d\u3048\u3089\u308c\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23601108\/\">Akamatsu et al., Cell Host Microbe 2013<\/a>)\u3002OsRacGEF1\u304b\u3099OsRacGEF2\u3068\u30d8\u30c6\u30ed\u30bf\u3099\u30a4\u30de\u30fc\u5316\u3059\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3057\u3001 \u30bf\u3099\u30a4\u30de\u30fc\u5316\u3057\u305fGEF\u304b\u3099\u30ad\u30c1\u30f3\u3084\u30d5\u30e9\u30b7\u3099\u30a7\u30ea\u30f3\u53d7\u5bb9\u4f53\u306e\u30ad\u30ca\u30fc\u30bb\u3099\u30c8\u3099\u30e1\u30a4\u30f3\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3082\u898b\u51fa\u3057\u3066\u3044\u308b(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26251883\/\">Akamatsu et al., Plant Signal Behav 2015<\/a>)\u3002\u3053\u306eGEF\u306e\u30bf\u3099\u30a4\u30de\u30fc\u5316\u304b\u3099\u69d8\u3005\u306a\u53d7\u5bb9\u4f53\u30ad\u30ca\u30fc\u30bb\u3099\u306e\u4e0b\u6d41\u3066\u3099\u50cd\u304f\u591a\u69d8\u306aG\u30bf\u30f3\u30cf\u309a\u30af\u8cea\u306e\u5236\u5fa1\u306b\u91cd\u8981\u306a\u6a5f\u69cb\u306e\u4e00\u3064\u3068\u8003\u3048\u3089\u308c\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20 aligncenter\" src=\"https:\/\/www.rib.okayama-u.ac.jp\/plant_design\/wp-content\/uploads\/2020\/01\/f2.png\" alt=\"\" width=\"405\" height=\"283\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\uff3b\u53c2\u8003\u8cc7\u6599\uff3d<br \/>\n<a style=\"background-color: #ffffff;\" href=\"https:\/\/leading.lifesciencedb.jp\/2-e008\">\u2022 \u5ddd\u5d0e\u52aa\u300c\u690d\u7269\u306b\u304a\u3051\u308b\u514d\u75ab\u8a98\u5c0e\u3068\u75c5\u539f\u5fae\u751f\u7269\u306e\u611f\u67d3\u6226\u7565\u300d\u9818\u57df\u878d\u5408\u30ec\u30d3\u30e5\u30fc<\/a><\/p>\n<p><a href=\"http:\/\/first.lifesciencedb.jp\/archives\/7044\">\u2022 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