Group of Integrated Genomic Breeding

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Faculty staff

Prof. Dr. Toshio Yamamoto
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Assoc. Prof. Dr. Kiyotaka Nagaki
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Assist. Prof. Dr. Tomoyuki Furuta
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Lectures: Analytical Molecular Cytogenetics
Keywords: Centromere; Artificial chromosome; Nucleus; Chromatin

Summary of main research topics

Exploring and utilization of useful traits from diverse rice genetic resources
Rice is cultivated all around the world and shows numerous morphological and physiological differences in the form of phenotypic variations. Some of these variations have been used as genetic resources to improve rice plants so that they better satisfy human needs. Phenotypic variations are considered to be genetically controlled by the collective function of a large number of genes on rice genomes However, the genetic bases and biological functions of most of them are still unknown, which has prevented us from wider practical application of rice germplasms. We exploit useful phenotypic variations from a wide range of rice germplasms and clarify the genes involved with biological functions by aid of recent advances in genome information and technology. Also, we try to develop new breeding materials and propose more effective breeding methodologies.
Design and synthesis of ‘chromosomes’ carrying new genome information
Nuclei that have very complex structures and various functions are the most important organelles in eukaryotic cells. Nuclear DNA are divided and packed into chromosomes, enabling the accurate transmission of genetic information to daughter cells. Our research group is studying the molecular structures and functions of nuclei and chromosomes, mainly in plants. Our most recent goal is the development of plant artificial chromosomes to elucidate chromosome functional elements: centromeres, telomeres, and replication origins. We are also interested in the relation between chromatin modifications and gene expression.

Latest publications (for complete and most current publications visit group pages)

(1) 長岐清孝 第5 章ヒト染色体と染色体のふるまい(分担執筆).エッセンシャル遺伝学・ゲノム科学[原著第7 版](中村千春・岡田清孝編)ISBN 978-4-7598-20 (2021. 1.)
(2) Ishii, T., Nagaki, K. and Houben, A. Application of CRISPR/Cas9 to visualize defined genomic sequences in fixed chromosomes and nuclei.(分担執筆)Cytogenomics ISBN 9780128235799 (2021. 5.)
(3) 上田忠正・石丸 健・後藤明俊・一家崇志・近藤勝彦・松原一樹・林 武司・山本敏央・田中淳一 日本のイネ品種を背景とした準同質遺伝子系統の比較栽培による収量関連9 対立遺伝子の遺伝的効果.育種学研究 23: 16-27. (2021. 5.)
(4) Zhang, G., Liu, Z., Liu, Y., Kuya N., Hua, Y., Shi, H., Zhao, W., Han, Y., Yamamoto, T., Chen, W. and Sun, J. iTRAQBased Proteomics Investigation of Critical Response Proteins in Embryo and Coleoptile During Rice Anaerobic Germination. Rice Science 28: 391-401. (2021. 7.)
(5) Nagaki, K., Furuta, T., Yamaji, N., Kuniyoshi, D., Ishihara, M., Kishima, Y., Murata, M., Hoshino, A. and Takatsuka, H. Effectiveness of Create ML in microscopy image classifications: A simple and inexpensive deep learning pipeline for non-data scientists. Chromosome Res. (2021. 10. Online preview)

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